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Histone deacetylases (HDAC2), a member of the HDAC family, is correlated with insulin signaling components in postsynaptic glutamatergic neurons of the adult mouse hippocampus, and hyperactivity of the HDAC system (including HDAC2) may result in the suppression of the insulin signaling system and consequent disruption of synaptic plasticity in type 2 diabetes

Similarly, elevated levels of L-CN mitigate free fatty acid-induced and obesity-related endothelial dysfunction, which is associated with obesity 33

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The carnitine bound OCTN2-occluded structure defines the substrate and sodium ion binding sites In the presence of 10 mM l-carnitine the structure of OCTN2 was determined in the fully occluded, carnitine- and Na + -bound conformation (Fig