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GLP-1 agonists mimic a natural hormone called glucagon-like peptide-1

Some patients on semaglutide have reported this complication

It is a tool that supports metabolic function and, when combined with appropriate diet and exercise, can enhance fat loss outcomes

In the manufacturers STEP trials reported in the FDA Wegovy prescribing information and the New England Journal of Medicine, adults without diabetes lost on average about 15 percent of body weight over 68 weeks alongside lifestyle changes

Resolves without intervention in 95% of cases

The Bottom Line Managing DPP-4 enzyme activity naturally represents the other side of the GLP-1 optimization equation