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Kratz EM, Piwowar A, Zeman M, Stebelov K, Thalhammer T

doi: 10.1016/j.mce.2017.05.015 134 AbdulHussainGAziziehFMakhseedMRaghupathyR

In preclinical models, Dihexa demonstrated superior pharmacokinetic properties, including good oral activity and effective BBB penetration, along with enhanced metabolic stability with a half-life of 335.5 minutes