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Self-inject into your mid-thigh quadriceps for easy access and safety, or ask someone to inject into your deltoid/shoulder, and ensure you're reaching muscle tissue, not just subcutaneous fat, for optimal results

Her recommendation is to map out the long game with your doctor up front, so you can decide together whether to continue, lower the dose, or stop down the road

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After that initial period, it is common to continue injections monthly, though less frequent intervals might be OK if cobalamin blood levels are supportive

Matching a high tirzepatide dose directly to retatrutide therefore introduces the heart-rate, liver-fat, and fat-release effects of glucagon all at once