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subsequently, prolonged incubation with the combination of GLP-1 and GIP improved insulin secretion in both diabetic and not diabetic human islets, and the combination of GLP-1 and GIP receptor agonists enhanced insulin gene expression and PDX-1 (-cell differentiation factor) expression and increased -cell survival
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Each category works through a different mechanism, carries a different level of clinical evidence, and comes with its own cost and safety considerations, so understanding the distinction matters before choosing one
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