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Timing of administration relative to surgical procedures, optimal dosing in perioperative settings, and integration with standard post-operative care protocols require clinical investigation before establishing evidence-based perioperative protocols

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The central hypothesis of the gut-liver axis is that translocation of luminal microbiota or microbial products (pathogen-associated molecular patterns or PAMPs) through an impaired intestinal barrier function is an early step in the pathogenesis of chronic liver disease (130)

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This epigenetic event activates the downstream FUS/AGT signaling axis, thereby fueling vascular remodeling and highlighting a novel therapeutic target for OSA-induced PH