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Mainly works on one pathway, the GLP-1 receptor

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Several surrogate systems have been developed to examine the relevance of these interactions and to study E1/E2 structure and function

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What can and cannot be claimed From this evidence structure, the defensible statements are narrow: IGF-1 LR3 is a receptor-active, IGFBP-resistant IGF-1 analog that is more potent than native IGF-1 in cell and animal models and is a valuable culture reagent

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