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The most-cited animal work is a series of long-term experiments in CBA mice and Wistar rats reporting that pulsed administration of Epitalon increased mean and maximum lifespan, reduced the incidence of spontaneous tumour formation, and preserved oestrous cyclicity in females past the age at which controls became acyclic

[Sakata K

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[7] This dual route is the mechanistic feature that most clearly separates survodutide from GLP-1 mono-agonists in the liver-disease setting, where reducing hepatic fat is the entry point to slowing inflammation and, eventually, fibrosis

Tandogan B, Ulusu NN