Evidence: The strongest data come from a large meta-analysis involving over 100,000 patients
Arch Neurol, DOI: 10.1001/archneur.1992.00530350051019 Passeri, M., Cucinotta, D., Bonati, P
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The researchers noted the excess risk was concentrated in certain groups: older adults (even within the 18 to 65 range) men people with more advanced diabetes people with existing eye disease people with cardiovascular conditions Thats important because type 2 diabetes itself is already a known risk factor for one common form of this condition, nonarteritic anterior ischemic optic neuropathy , which makes up about 75% of ischemic optic neuropathy cases
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After 24 weeks treatment, there were no significant differences between the groups for the primary endpoint of change in left ventricular ejection fraction, regardless of whether the patients had comorbid diabetes or not
