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also discovered this mechanism in a high-fat diet rat model, there is a reduction of the NOD-like receptor family, pyrin domain containing 3 inflammasome (NLRP3) and caspase 1 (Zhang et al., 2018)

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Understanding follicular development through multi-omics approaches has revealed complex molecular signatures that reflect ovarian reserve, follicular health, and the aging process, providing clinically relevant biomarkers for fertility assessment and treatment optimization