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It is fat loss with function preserved

Drugs that rely on a specific pH environment for dissolution, or those formulated to release their active ingredient gradually over time, are particularly susceptible to altered absorption

During an IR state mitochondrial oxidative phosphorylation is suppressed (because of mitochondrial dysfunction and/or reduced mitochondrial content)

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Because semaglutide delays gastric emptying, there has been some discussion in clinical circles about whether this might theoretically reduce the absorption of oral contraceptives

More studies are needed before such strong statements can be made