Richardson SM, Hughes N, Hunt JA, Freemont AJ, Hoyland JA: Human mesenchymal stem cell differentiation to NP-like cells in chitosan-glycerophosphate hydrogels
This unexpected double-strand break not only may randomly damage functional genes, trigger cell apoptosis or functional disorders, but also may cause large-scale chromosomal translocations or rearrangements through incorrect DNA repair mechanisms, significantly increasing genomic instability
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Enhanced polyol pathway flux drives oxidative stress, and the accumulation of advanced glycation end-products (AGEs) triggers RAGE-dependent inflammatory signaling [96]
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