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Insulin resistance: STAT3/SOCS signaling suppresses insulin/IGF-1 pathway The signaling pathways of several cytokines and growth factors, such as insulin/IGF-1, converges at the activation of STAT3 factor (Figs

One such pathway is the formation of peroxynitrite by a reaction of nitric oxide (NO) and superoxide radical

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M2 macrophages exhibit angiogenic and proinvasive properties, producing growth factors, chemokines, and MMPs that stimulate tumor growth, invasion, and metastasis (93), particularly facilitating tumor cell extravasation and growth in secondary sites