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Since DFO is membrane impermeable and accumulates in lysosomes 18 , we believe that it protects the cells against ferroptosis by chelating lysosomal iron as described previously 47

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Additional information Prior Presentation: This manuscript is based on work that was presented at the American Diabetes Association83rd Annual Scientific Sessions, San Diego, CA, USA, 2326 June 2023: 769-P: Effect of food on the pharmacokinetics, safety and tolerability of orforglipron (LY3502970) an oral, non-peptide GLP-1 receptor agonist

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Ludvik B, Giorgino F, Jodar E, Frias JP, Fernandez Lando L, Brown K