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Many patients benefit from a brief medication pause (under medical supervision) before restarting or switching compounds, as this can restore receptor sensitivity

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The most common issues are gastrointestinal symptoms such as: 3 Nausea Diarrhoea Vomiting Constipation Abdominal discomfort These side effects were dose-dependent

Although GLP-2 can also blunt inflammatory cytokine production via inhibition of NF-B activity and ERK phosphorylation (63), enhanced macrophage accumulation was observed in the colon of colitic mice (35)

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Note: Both formats require a titration period