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P., De Meyer, G

This dual action supports both memory formation and mood regulation, as healthy BDNF levels are associated with cognitive function and mood balance

the National Key R&D Program of China (2022YFC2703105 to HEX)

Results GSDMD-mediated pyroptosis is activated in ischemic hindlimbs To investigate the involvement of GSDMD-mediated pyroptosis in hindlimb ischemic injury in vivo, we established hindlimb ischemia (HLI) model by ligation of the femoral artery in wild-type (WT) mice

This multimodal approach targets pain through both the central nervous system and peripheral inflammation

A single GH molecule engages two receptor subunits asymmetrically through site 1 and site 2 binding, producing a rotational realignment that activates intracellular signaling