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Uncoupling of eNOS is thought to be a key player in atherosclerosis.[ref][ref] Tetrahydrobiopterin deficiency is a major cause of eNOS uncoupling

BB formation begins in a location anatomically proximal to TMA formation and is quantitatively a major gut microbial metabolite of L -carnitine To further assess the relative synthetic capacity and location(s) along the intestinal tract for BB and TMA formation from both L -carnitine and BB, we co-incubated molar equivalent amounts of synthetic L -d3(methyl)-carnitine and d9(trimethyl)-BB with distinct anatomic segments of mouse intestines (including luminal contents) and then examined production of the various trimethylamines (carnitine, BB, TMA)

L-Carnitine (PCOS)