Anecdotally, some users report experiencing gastrointestinal issues like nausea, diarrhea, or constipation, as well as headache, fatigue, or irritation at the injection site
doi:10.1136/bmj-2021-066452
The main drawbacks involve needle discomfort, potential injection site reactions, and the requirement for sterile technique
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Furthermore, BPC-157 is a potent stimulator of F-actin production in fibroblasts, which was revealed by experiments using FITC-phalloidin staining, and analysis by Western blotting showed that BPC-157 enhances phosphorylation of paxillin and FAK proteins - critical proteins in the cell migration pathway
Investigators should design trials to accommodate participants with schedule conflicts by, for example, offering early morning or late evening hours