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For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]

According to Shuja et al 11 study, risk factors for melasma other than GSH, there was also a decrease in levels of other antioxidants such as superoxide dismutase (SOD), catalase, vitamin E, and vitamin C which were statistically significant in melasma subjects compared to controls