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It also reduces hepatic fat accumulation, which independently worsens insulin sensitivity a relevant secondary benefit given that non-alcoholic fatty liver disease is significantly more prevalent in women with PCOS

Thus GLP-1 was shown to regulate a number of diverse functions: reduction in digestive enzyme secretion, slowing of gastric motility, increases in heart rate and blood flow, increased bone remodeling, and suppression of appetite (via hypothalamic and brainstem nuclei)

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Eur J Biochem 268(2):317325 Diederich M, Wellman M, Visvikis A, Puga A, Siest G (1993) The 5 untranslated region of the human gamma-glutamyl transferase mRNA contains a tissue-specific active translational enhancer

It plays a crucial role in cellular processes, including detoxification and antioxidant defense