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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

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Neither compound is better than the other, since theyre studied for entirely different mechanisms AOD-9604 for hGH-fragment-related lipid metabolism, MOTS-c for mitochondrial energy signaling