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But one of the major ways that glutathione protects cells from damage by oxidants is by recycling other vitamins, including vitamins C and Eboth powerful antioxidants themselves

Disease Prevention: Studies suggest that individuals with higher levels of reduced glutathione have a lower risk of developing chronic diseases

The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction

Updated June 20, 2024