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Regarding thyroid effects: rodent studies with related GLP-1 receptor agonists have shown C-cell changes, but no causal link to thyroid tumours in humans has been established in UK or EU regulatory assessments

Numerous studies have also shown how important the portal glucose sensor is in maintaining glucose homeostasis and how GLP- 1 receptors are related to portal glucose sensing, with GLP- 1 being required for portal glucose to trigger the insulin response

High blood sugar : When there is too much sugar in the bloodstream

Clinical outcomes The primary end points were the participant incidence of TEAEs, changes in laboratory safety tests, vital signs and 12-lead electrocardiograms

These typically ease off by week four

These are rare with GLP-1 medications but require emergency response if they occur