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REDEFINE 1 evaluated the combination in adults with overweight or obesity without type 2 diabetes over a 68-week design, comparing the combination against the individual components and placebo [5]

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BPC-157: Maintain 250-500 mcg twice daily Cryotherapy: Reduce to 2-3 local ice applications daily Consider contrast therapy (alternating cold and heat) if swelling has decreased Begin gentle range-of-motion exercises if pain permits Shift emphasis toward tissue repair while maintaining inflammation control

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