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Studies have suggested that IGF-2 signaling may contribute to endothelial dysfunction and smooth muscle proliferation, both of which are critical pathological features of PAH (Tan et al., 2021)

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Liu G, Zhu J, Cai C, Zhou Y, Yu M, Fu Z, Gong Y, Yang B, Li Y, Zhou Q, Lin Q, Ye H, Ye L, Zhao X, Li Z, Chen R, Han F, Tang C, Zeng B (2015) Glutamate dehydrogenase is a novel prognostic marker and predicts metastases in colorectal cancer patients

Advanced fibrosis (stage 3) is associated with a higher risk of developing hepatic decompensation (ascites, variceal bleeding, and hepatic encephalopathy), need for liver transplantation, and increased mortality