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But Loren and other people on the drugs told USA TODAY while their taste has changed, their relationship with food feels better than ever

In people with lower starting weights, small doses could have big impacts, he says

A 2009 study 15 showed berberine could help lower HgA1C from 8.3% to 7.1%, similar to prescription diabetic drugs

Beyond nausea, the gastrointestinal side effect cluster includes diarrhea, vomiting, constipation, and decreased appetite, which is technically a desired effect but can become problematic at extreme levels

Although that may not seem like a lot, it translates to about 7.6 million fewer adults with obesity

TripleHormone-Receptor Agonist Reta for ObesityA Phase 2 Trial