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Several studies have indicated that cartilage matrix homeostasis is impaired in selenium deficiency
Androgen/AR complex binding to antioxidative response elements (AREs) containing promoters of target genes disrupts Wnt agonist/antagonist balance involved in DPC-inductive ability, such as dickkopf-1 (DKK1), which is a specific inhibitor of Wnt coreceptors of the LRP family 29
On the other hand, baseline measurements found that levels of IL-10 in APP/PS1 mice were significantly reduced in comparison to wild type mice, and when treated with Dihexa these mice experienced an increase in IL-10 levels
Prussian blue histological staining showed a marked increase in iron deposition in groups receiving the high-iron diet (Figure 1B)