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In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date
Combining medications can increase the risk of side effectsespecially gastrointestinal symptoms like nausea and vomitingand there may be unknown interactions between drugs
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Semaglutide in Patients with Heart Failure with Preserved Ejection Fraction and Obesity
Understanding Semaglutide: A GLP-1 Receptor Agonist Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist (a medication that mimics a natural hormone regulating blood sugar and appetite)
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