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A 2026 study using alanine substitution of phosphorylation sites with single-residue resolution demonstrated that the distal C-tail site primarily governs -arrestin recruitment dwell time, while proximal sites control internalization rate and cAMP duration (Tran et al., 2026)

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Moreover, the increased YAP activity is modulated by RhoA signaling

*Correspondence: Dongyi He, [email protected] This article was submitted to Autoimmune and Autoinflammatory Disorders: Autoimmune Disorders, a section of the journal Frontiers in Immunology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers