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Results of routine laboratory testing (mild to marked increases in ALT and globulins while ALP and GGT are typically normal) and ultrasonographic examination (hepatomegaly, generalized increase in hepatic parenchymal echogenicity) 4a of the liver may be supportive, but definitive diagnosis relies on histopathologic examination of a liver biopsy

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But also different methylation processes, due to a B12-related deficiency of S-adenosylmethionine, seem to be causally involved in neuropsychiatric problems

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Notably, there is a prominent sex difference in the prevalence of ASD, with prevalences of 2.8% in males and 0.65% in females and a male-to-female ratio of 4.3:1