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When calories decrease sharply, less energy reaches the follicles

Additionally, the long-term safety concerns associated with single-pathway metabolic modulators must be considered

doi: 10.1016/S0140-6736(19)31149-3 40 BaileyCJFlattPRConlonJM

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Experimental and clinical data demonstrate that reductions in circulating testosterone are associated with diminished lean mass and unfavorable alterations in fat distribution [13]