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Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins

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Much of its human evidence comes from outside the United States and from a single research lineage a combination that places epithalon firmly outside the category of established, approved therapeutics

Insufficient time on treatment is another common explanation

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[See Warnings and Precautions (5.4).] Risk Summary The limited available data with JANUVIA in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage