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In his search for an incretin, Holst began investigating hormones secreted by intestinal endocrine L cells

Incretins are also responsible for other functions both inside and outside the pancreas

While glucagon historically raised concerns because it elevates blood sugar, the combination with GLP-1 activity shifts the effect toward increased energy expenditure rather than hyperglycemia

Part 3: teratogenicity and reproductive toxicity studies in rats

Which is better for weight loss, Zepbound or Wegovy

Among participants who completed 12 weeks without discontinuing, 87% went on to achieve at least 15% weight loss by the end of the study