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Real-world effectiveness Studies examining real-world outcomes show that results are typically somewhat lower than in clinical trials but still significant: A 2025 Cleveland Clinic study found average weight loss of 10-15% in routine clinical practice (compared to 15-22% in trials)

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Consequently, SGLT2 inhibitors reduce blood glucose levels, lower insulin secretion, and increase glucagon secretion [6]

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doi: 10.1016/j.jconrel.2024.03.040 149 LiuZLiuKShiSChenXGuXWangWet al

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