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This section will briefly review what we know about the current safety data of GLP-1 and GLP-1/GIP agonists, and factors that may promote long term clinical use of these agents in obesity

Both pyruvate and TCA cycle intermediates accumulation is consistent with the NAD + recycling activity of Cr GPDH, which is similar to the NAD + recycling activity of a water-forming NADH oxidase Lb NOX 16,27

Trial outcomes are useful, but they do not replace individualized care

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