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This is the fundamental cellular reason why weight loss leads to muscle loss

According to data from the 72-week SURMOUNT-1 trial, participants on the maximum dose experienced an average weight loss of 18% of their body weight , with 36.2% achieving a significant reduction in weight[1]

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These receptors are located in the pancreas, gastrointestinal tract, heart, kidney, and brain, allowing broad effects in experimental models