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Selenocysteine insertion sequence binding protein 2 (SBP2) binds to selenocysteine insertion sequence (SECIS) element which is located in the 3-untranslated region (3UTR) of selenoprotein mRNA, and mediates the transfer of Sec-tRNA [Ser]Sec to the A-site of ribosome which recognizes the UGA codon as the Sec integration codon