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SEMA was shown to be the most effective of its category in terms of meaningful weight reduction as it can penetrate certain areas in the central nervous system that are critical for hunger and appetite control and are not protected by the blood-brain barrier, regulating key appetite-modulating relay areas [70, 73]

J Am Soc Nephrol 2010;21:527-35.ArticlePubMedPMC 13

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But beyond this, their weight regain plateaus, with individuals managing to keep off 25% of the weight lost to treatment, researchers at the University of Cambridge have concluded

Patients should be counselled to avoid such exposures unless the product information specifically states otherwise