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Additionally, we revealed that PPARa regulates FSP1 as a transcription factor, promoting CoQ10-NAD(P)H cycling and generating reactive thiol antioxidants

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Among these cytokines and chemokines, CSF2 has been reported to control microglia activity and contribute to neuroprotection in brain inflammation ( FIGURE 1 We next ran the gene set enrichment analysis (GSEA) for all the 2,637 differentially expressed genes in GSTM1 KD astrocytes after TNF- stimulation