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Severe gastrointestinal reactions also open the route to the labeled warning on acute kidney injury due to volume depletion, which has included cases requiring haemodialysis in patients treated with this drug class

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Average weight loss of 10 to 15% of body weight in clinical trials

The first month on tirzepatide typically produces 3 to 5 pounds of weight loss, much of which is water weight and reduced food volume from appetite suppression

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[DOI] [PubMed] [Google Scholar] McCord JM, Fridovich I