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IL-13 exerts its anti-angiogenic function via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway (90), and it also can reduce the death of chondrocytes to protect the cartilage from destruction probably because of the reduction of Fc gamma receptor I (FcRI) (91)

The laboratory animals were housed in PC cages in conventional laboratory conditions at a temperature of 22.4 C, a relative humidity of 4070%, and a noise level of 60 dB

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