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Semaglutide, GLP-1 Drugs, and IBS: Managing Side Effects and Gut Health Aleks Jagiello BSc, MSc, RD Sep 11, 2025 17 min read Glucagon-like peptide-1 (GLP-1) receptor agonist medications, such as semaglutide (brand names Wegovy, Ozempic ), have surged in popularity for weight loss and type 2 diabetes management

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As a result, vitamin B12 deficiency affects between 1.5% and 15% of the public

These effects can lead to damage to cells and tissues, further burdening the liver and other organs involved in detoxification

Medical conditions: Certain health conditions, such as diabetes, thyroid disorders, nerve compression (radiculopathy), spinal stenosis, and liver disease (e.g., cirrhosis), can increase the risk

( in vivo binding of 4-bromophenol in rat GSTM2 and confirmed adducts by radioactive labeling, tryptic digestion and LC-MS/MS