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Am J Physiol Regul Integr Comp Physiol 292(1):R18-36

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Ipamorelins impact is less hypothalamic and more pituitary-local, so together they alter central feedback loops without completely supplanting hypothalamic control

On the other hand, lipolysis in adipose tissues increases hepatic acetyl CoA levels and pyruvate carboxylase activity which further promotes hepatic glucose production