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For the efficacy estimand, the LSM change in HbA1c from baseline at week 52 as the primary endpoint was 2.24%, 2.43%, and 2.58% with tirzepatide 5, 10, and 15 mg, respectively, versus 1.44% with insulin glargine

How Retatrutide and Mounjaro Work in the Body Both Retatrutide and Mounjaro fall under incretin-based therapies

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The prevalence of other optic nerve disorders was 0.12% among semaglutide- or tirzepatide-treated patients, compared to 0.07% among patients receiving non-GLP-1RA antidiabetic medications

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