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These effects have generally been reported as diminishing over time in longer trial windows for both compounds

Crowley, H

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It involved almost 18,000 participants with excess weight or obesity and cardiovascular disease who took weekly Wegovy injections for four years while also making lifestyle changes, such as following a reduced-calorie diet and increasing physical activity

The choice often comes down to whether you prefer the convenience of pen devices at $969 monthly or can accept the minor inconvenience of vials in exchange for dramatic cost savings