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IGFBP-2 is the second most abundant binding protein in adult serum and is often elevated in catabolic states and in certain cancers, where it has attracted study as a biomarker

In hospital settings, it is also used as an antidote for paracetamol overdose (IV formulation at doses of up to 150mg/kg) and in nebulized format in patients with acute bronchopulmonary disease (pneumonia, bronchitis, tracheobronchitis)

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These data confirmed the primary results, with estimated effect size of 3.8% (95% coverage 5.5, 2.2) reduction in HFF