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The foundational mechanism papers from the Washington State University lab that described how Dihexa works were retracted in April 2025 following a misconduct finding, with a third paper under an Expression of Concern since 2021

In tumors, persistent ROS elevation increases GSH synthesis and shifts the redox balance, creating a biochemical environment that selectively activates disulfide/diselenide linkers and metal-based GSH-depleting nanoplatforms

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2.9 Inductively coupled plasma mass spectrometry (ICP-MS) assay L-02 cells were cultured in 10 cm dishes at an initial density of 4 10 5 cells per dish and treated with either 0 or 600 M CGA

Mechanisms of Development 129 , 98108 (2012)