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Introduction Glutathione is an antioxidant molecule seen as a fundamental component in the response to oxidative stress in the brain ( via Nrf2 pathways ( in vivo measurement of GSH from the brain using Magnetic Resonance Spectroscopy (MRS) has produced inconsistent results to date

MOTS-c (Mitochondrial-Derived Peptide) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome (specifically the 12S rRNA gene)

5 How They Compare: Mechanism and Clinical Evidence Both NAC and glutathione ultimately support the same biological outcome -- higher intracellular glutathione and lower oxidative burden -- but they operate at different points in the pathway and carry different clinical evidence profiles

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Pregnant or Breastfeeding Women: The safety of these peptides during pregnancy or breastfeeding has not been established, and therefore should be avoided by these populations

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