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The C-terminal difference between the two variants makes GAC more specifically active, which may contribute to its greater susceptibility to overexpression in aggressive cancers (Redis et al., 2016)

LDL cholesterol (the 'bad' cholesterol linked to plaque buildup) also declined, though the effect was more modest than triglyceride reduction

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One large observational study found higher risk for diabetes in younger adults with low IGF-1, but not in adults older than 65

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