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Nausea, vomiting, diarrhea, and constipation affected 60 to 80% of participants at higher doses, though most symptoms were mild to moderate in severity

1.4% of placebo, highlighting tolerability challenges that may require optimization of dosing strategies or formulations [23]

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The dried films were hydrated with 1 mL of 1X DPBS (pH 7.4), heated in a water bath at 42 C for 30 min, and subjected to ultrasonication using a probe tip sonicator (Fisher Scientific) for a total of 30 min (20 s on/40 s off cycles) at 42 C in the dark